The study of entrepreneurship in mountainous areas is a young field of research. This paper aims at analyzing the characteristics of entrepreneurship in the new municipality of Konitsa. For this purpose, a field research was conducted through semi-structured interviews to a representative sample of 49 entrepreneurs. The results highlight the particularities of entrepreneurship in mountain regions. Characteristics such as the location, the difficulty of access, the natural and human resources, etc., influence both positively and negatively the entrepreneurial activity. Through this analysis, the problems and the developmental potential are examined and, finally, a number of potential measures are proposed in order to effectively support the mainly small-scale family enterprises in the area.