Water resource management is a complex and demanding procedure. Hence, continuous monitoring and updating of the anthropogenic pressures on water bodies is necessary, including both the current state and the response. The case study of Kalamas water body is strongly connected with the natural and the socioeconomic environment in the Municipality of Zitsa. In this context, this paper presents the composition of an inventory of point and diffused human-induced pressures for four major parameters affecting water quality. The contribution of several activities to the pollution of Kalamas river is also assessed. Furthermore, the river's quality status is presented according to recent measurements, and an integrated plan for dealing with existing pressures is proposed.