This year a new law, named “Callicrates”, rearranged the boundaries of all the Greek Municipalities. Despite of the theoretically stated intentions, “Callicrates” is an important potential threat to the future development and prosperity of mountain regions. Already at the margin of development, mountain areas will get even more marginalized under the implementation of the new law. In this paper, the spatial parameters of the newly founded Municiplity of Metsovo are studied. The current social and economic situation of the region is analyzed. The spatial inequalities, as well as the main sections related to them, are pointed out and specific actions are suggested to the direction of a balanced development for the area. The different developmental level of each settlement, their special growth problems, as well as their unique potentials comprise, at the same time, the cause of inequality and the base for a prosperous development policy.