Zagori is a place with a rich natural and cultural heritage. A typical example is the folk medicine tradition of the region with the famous “Vicoyiatroi”, which was based on the richness of the local flora. Nowadays, this forgotten tradition can be a trigger for developing new entrepreneurial activities, which could create job opportunities and keep young people in the area.

On this basis, this paper investigates the economic viability of a business idea regarding the trade of aromatic and medicinal plants in the region of Zagori. For the purposes of the survey, two alternative scenarios were considered namely, a self-employed business and a very small business, which differ in terms of the investment required, the size of the operation and the characteristics of sales.